Multiomics insights into BMI-related intratumoral microbiota in gastric cancer.

ABSTRACT:

Introduction

Body mass index (BMI) is considered an important factor in tumor prognosis, but its role in gastric cancer (GC) remains controversial. There is a lack of studies exploring the effect of BMI on gastric cancer from the perspective of intratumoral microbiota. This study aimed to compare and analyze the differences in and functions of intratumoral microbiota among GC patients with varying BMIs, aiming to ascertain whether specific microbial features are associated with prognosis in low-BMI (LBMI) gastric cancer patients.

Methods

A retrospective analysis of the clinicopathological features and prognosis of 5567 patients with different BMIs was performed between January 2010 and December 2019. Tumor tissues from 189 GC patients were collected for 16S rRNA sequencing,

SUBMITTER: Liu K 

PROVIDER: S-EPMC11876552 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature