Global, regional, and national burden of retinoblastoma in children aged under 10 years from 1990 to 2021 and projections for future disease burden.

ABSTRACT: Retinoblastoma, the most common intraocular malignancy in children, represents a significant global health challenge, particularly in low- and middle-income countries, where delayed diagnosis and limited access to care persist. Despite advances in diagnostic and therapeutic approaches, disparities in disease burden remain pronounced. Data on retinoblastoma incidence, prevalence, deaths, and disability-adjusted life years (DALYs) from 1990 to 2021 were extracted from the Global Burden of Disease Study 2021. Countries were categorized into 21 regions, with additional classification by Socio-demographic Index. Linear regression analysis was used to estimate the annual percentage change in age-standardized rates, and future trends were projected using a Bayesian age-period-cohort model. The gl

SUBMITTER: Zhu H 

PROVIDER: S-EPMC11876563 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature