Bidirectional Mendelian randomization study reveals interplay between multisite chronic pain and Post-traumatic stress disorder.

ABSTRACT: To determine the causal relationship between multisite chronic pain (MCP) and post-traumatic stress disorder (PTSD) using Mendelian Randomization (MR) analysis. Genome-wide summary statistics for MCP and PTSD were obtained. Linkage disequilibrium score regression (LDSC) analysis was used to assess genetic correlation. Independent SNPs associated with MCP and PTSD were used as instrumental variables for forward and reverse MR analyses. The inverse variance weighted (IVW) method was the primary analysis, with additional sensitivity tests to ensure robustness. LDSC identified a significant genetic correlation between MCP and PTSD (rg = 0.635, P = 1.40E-110). The forward MR analysis indicated a positive causal association between the number of MCP sites and the PTSD risk (Odds Ratio [OR] = 1.1

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11876571 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature