Metformin-regulated glucose flux from the circulation to the intestinal lumen.

ABSTRACT:

Background

Through a retrospective analysis of existing FDG PET-MRI images, we recently demonstrated that metformin increases the accumulation of FDG in the intestinal lumen, suggesting that metformin stimulates glucose excretion into the intestine. However, the details of this phenomenon remain unclear. We here investigate the detailed dynamics of intestinal glucose excretion, including the rate of excretion and the metabolism of excreted glucose, in both the presence and absence of metformin.

Methods

We quantified intestinal glucose excretion using newly developed FDG PET-MRI-based bioimaging in individuals with type 2 diabetes, both treated and untreated with metformin. The metabolism of excreted glucose was analyzed through mass spectrometry of fecal samples from mice in

SUBMITTER: Sakaguchi K 

PROVIDER: S-EPMC11876595 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature