Cellular interactions within the immune microenvironment underpins resistance to cell cycle inhibition in breast cancers.

ABSTRACT: Immune evasion by cancer cells involves reshaping the tumor microenvironment (TME) via communication with non-malignant cells. However, resistance-promoting interactions during treatment remain lesser known. Here we examine the composition, communication, and phenotypes of tumor-associated cells in serial biopsies from stage II and III high-risk estrogen receptor positive (ER+ ) breast cancers of patients receiving endocrine therapy (letrozole) as single agent or in combination with ribociclib, a CDK4/6-targeting cell cycle inhibitor. Single-cell RNA sequencing analyses on longitudinally collected samples show that in tumors overcoming the growth suppressive effects of ribociclib, first cancer cells upregulate cytokines and growth factors that stimulate immune-suppressive myeloid different

SUBMITTER: Griffiths JI 

PROVIDER: S-EPMC11876604 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature