Leveraging prior knowledge to infer gene regulatory networks from single-cell RNA-sequencing data.

ABSTRACT: Many studies have used single-cell RNA sequencing (scRNA-seq) to infer gene regulatory networks (GRNs), which are crucial for understanding complex cellular regulation. However, the inherent noise and sparsity of scRNA-seq data present significant challenges to accurate GRN inference. This review explores one promising approach that has been proposed to address these challenges: integrating prior knowledge into the inference process to enhance the reliability of the inferred networks. We categorize common types of prior knowledge, such as experimental data and curated databases, and discuss methods for representing priors, particularly through graph structures. In addition, we classify recent GRN inference algorithms based on their ability to incorporate these priors and assess their perfo

SUBMITTER: Stock M 

PROVIDER: S-EPMC11876610 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature