Fetal-to-fetal kidney transplantation in utero.

ABSTRACT: Potter sequence consists of various symptoms associated with renal dysplasia. For bilateral renal agenesis, there is no hope of survival. As a novel therapeutic approach for Potter sequence, we develop a unique approach of "transplantation of fetal kidneys from a different species during the fetal stage." In this study, we first validate the approach using allogeneic transplantation. Fetal kidneys with bladders from green fluorescent protein-expressing rats (embryonic day 14.0-16.5) are subcutaneously transplanted into allogeneic rat fetuses in utero (embryonic day 18.0-18.5). After birth, the transplanted fetal kidneys are confirmed to have urine production capability. Furthermore, long-term (up to 150 days) urine production is sustained. Next, we perform xenotransplantation. The transpla

SUBMITTER: Morimoto K 

PROVIDER: S-EPMC11876676 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature