Glycogen synthase is required for heat shock-mediated autophagy induction in neuronal cells.

ABSTRACT: Autophagy is an essential cellular process that facilitates the degradation of aggregated proteins and damaged organelles to maintain cellular homeostasis and promote cell survival. Recent studies have indicated a direct role for glycogen synthase (GS) in activating neuronal autophagy and in conferring protection against cytotoxic misfolded proteins. Since heat shock induces protein misfolding and autophagy is an essential component of the heat shock response that clears the misfolded proteins, we looked at the possible role of GS in heat shock response pathways in neuronal cells. We demonstrate an increase in the activity and level of GS and a concomitant increase in the glycogen level during the heat shock and post-heat shock recovery period. These changes had a direct correlation with a

SUBMITTER: Bhadauriya P 

PROVIDER: S-EPMC11876841 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature