Statin Use and Amyotrophic Lateral Sclerosis Survival: A Population-Based Cohort Study.

ABSTRACT:

Background

Dyslipidemia is common in amyotrophic lateral sclerosis (ALS). Statin use has been associated with both favorable and poor prognoses. We assessed whether statin use affects ALS survival.

Methods

We linked four Norwegian health surveys (1972-2003) with mandatory national registries to obtain information on premorbid health, ALS diagnosis, and death. Using the Norwegian Prescribed Drug Registry, we identified participants who had dispensed statins pre- and post-diagnosis. We first compared pre-diagnosis statin discontinuation rates between ALS patients and matched controls. Flexible parametric models were then fitted to estimate the relationship between statin use and survival time in ALS, using restricted mean survival time and hazard ratio (HR) as effect measures.

SUBMITTER: Vaage AM 

PROVIDER: S-EPMC11876845 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature