Cost-effectiveness of an outreach program for HCC screening in patients with cirrhosis: a microsimulation modeling study.

ABSTRACT:

Background

Patients with cirrhosis are at high risk for hepatocellular carcinoma (HCC), but few undergo guideline-recommended semi-annual screening. Randomized clinical trials (RCTs) demonstrate that mailed outreach can increase screening versus visit-based screening. We estimated the costs and cost-effectiveness of an outreach strategy versus usual care.

Methods

We built a 10-year Markov chain Monte Carlo microsimulation model to conduct a cost-effectiveness analysis comparing a mailed outreach program versus usual care for HCC screening in a cohort of 10,000 patients with cirrhosis. Model inputs were based on literature review (2005-current), and costs were based on inflation-adjusted estimates from Surveillance, Epidemiology, and End Results (SEER)-Medicare claims data. W

SUBMITTER: Gurley T 

PROVIDER: S-EPMC11876903 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature