A resting-state fMRI cross-sectional study of cardiorespiratory fitness decline after stroke.

ABSTRACT:

Objective

The present study aimed to investigate alterations in neural activity and reorganization of functional networks within critical brain regions associated with reduced cardiorespiratory fitness (CRF) in stroke patients. By employing resting-state functional magnetic resonance imaging (fMRI), we sought to identify specific brain areas that may be implicated in CRF decline among this patient population.

Methods

A total of 22 patients with stroke and 15 healthy subjects matched for age, gender, and body mass index were recruited. Rehabilitation assessments included peak oxygen uptake (VO₂peak), peak work-rate, 10-meter walk test (10mWT), five times sit-to-stand test (FTSST), and 6-min walking distance (6MWD). Resting-state fMRI data were collected for the two

SUBMITTER: Qu Q 

PROVIDER: S-EPMC11877007 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature