Association of fluoroquinolones with the risk of spontaneous pneumothorax: nationwide case-time-control study.

ABSTRACT:

Introduction

Fluoroquinolones can cause severe collagen-associated adverse effects, potentially impacting the pulmonary connective tissue. We investigated the association between fluoroquinolones and spontaneous pneumothorax.

Methods

A case-time-control study was performed using the nationwide French reimbursement healthcare system database (SNDS). Cases were adults ≥18 years admitted for spontaneous pneumothorax between 2017 and 2022. For each case, fluoroquinolone use was compared between the risk period immediately preceding the admission date (days -30 to -1), and three earlier reference periods (days -180 to -151, -150 to -121, -120 to -91), adjusting for time-varying confounders. OR estimates were corrected for potential exposure-trend bias using a reference group with

SUBMITTER: Benard-Laribiere A 

PROVIDER: S-EPMC11877017 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature