Socioeconomic burden of AQP4-antibody seropositive NMOSD: a nationwide registry-based study.

ABSTRACT:

Background

AQP4-antibody seropositive (AQP4-Ab+) neuromyelitis optica spectrum disorder (NMOSD) may cause reduced work capability due to disability. Here, we evaluated the socioeconomic status of patients with AQP4-Ab+NMOSD in off-label therapy era compared with the general population.

Methods

A longitudinal nationwide population-based study including all Danish patients with AQP4-Ab+NMOSD and matched controls from the general population. The cohort was linked to other Danish nationwide population-based databases. The study period was from 1992 to 2021. The main outcomes were loss of income from salary, limited work capability, disability pension and civil status. The longitudinal risks of outcomes were presented in cumulative incidence curves. Fisher's exact test, χ^2</

SUBMITTER: Papp V 

PROVIDER: S-EPMC11877084 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature