Doxycycline Postexposure Prophylaxis and Sexually Transmitted Infection Trends.

ABSTRACT:

Importance

Increasing rates of sexually transmitted infections (STIs) have been associated with rises in serious morbidity. While doxycycline postexposure prophylaxis (doxyPEP), a strategy in which individuals take doxycycline, 200 mg, after condomless sex to prevent bacterial STIs, has been shown to be efficacious in randomized clinical trials, doxyPEP's potential effect on population-level STI incidence is unknown.

Objective

To assess the association of citywide doxyPEP guideline release with reported chlamydia, gonorrhea, and early syphilis cases in men who have sex with men (MSM) and in transgender women in San Francisco, California.

Design, setting, and participants

This population-level interrupted time series analysis of reported San Francisco STI cases measure

SUBMITTER: Sankaran M 

PROVIDER: S-EPMC11877200 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature