NapBiome trial: Targeting gut microbiota to improve sleep rhythm and developmental and behavioural outcomes in early childhood in a birth cohort in Switzerland - a study protocol.

ABSTRACT:

Introduction

The gut-brain axis plays a crucial role in the regulation and development of psychological and physical processes. The first year of life is a critical period for the development of the gut microbiome, which parallels important milestones in establishing sleep rhythm and brain development. Growing evidence suggests that the gut microbiome influences sleep, cognition and early neurodevelopment. For term-born and preterm-born infants, difficulties in sleep regulation may have consequences on health. Identifying effective interventions on the gut-brain axis in early life is likely to have long-term implications for the health and development of at-risk infants.

Methods and analyses

In this multicentre, four-group, double-blinded, placebo (PLC)-controlled randomised

SUBMITTER: Zimmermann P 

PROVIDER: S-EPMC11877202 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature