Multicentre double-blind randomised placebo-controlled four-arm trial to assess the effect of oral sodium bicarbonate and intravenous hyoscine butylbromide on spontaneous delivery after induction of labour in nulliparous women: protocol for the Safe Induction of Labour Trial (SAINT).

ABSTRACT:

Introduction

Presently, more than one in four births in high-income countries undergo labour induction. Induction of labour is an independent risk factor for adverse obstetric outcomes, including high rates of operative delivery. Two drugs, hyoscine butylbromide and sodium bicarbonate, have been used in labour to facilitate cervical dilation and prevent uterine lactate accumulation. However, no previous randomised trial has systematically studied the separate and combined effects of these drugs in women with induction of labour.

Methods and analysis

The Safe Induction of Labour Trial (SAINT) study will assess the efficacy of oral sodium bicarbonate and intravenous hyoscine butylbromide on facilitating spontaneous (ie, non-operative) delivery in nulliparous participants with

SUBMITTER: Sorbye IK 

PROVIDER: S-EPMC11877258 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature