Cytomegalovirus infection is associated with impaired myocardial flow reserve after heart transplantation.

ABSTRACT:

Background

Cardiac allograft vasculopathy (CAV) limits long-term survival after heart transplantation (HT). This study evaluates the relationship between clinically significant cytomegalovirus infection (CS-CMVi) and CAV using cardiac positron emission tomography (PET).

Methods

We retrospectively evaluated HT patients from 2005 to 2019 who underwent cardiac PET for CAV evaluation. Multivariable linear and logistic regression models were used to evaluate the association between CS-CMVi and myocardial flow reserve (MFR). Kaplan-Meier and Cox regression analyses were used to assess the relationship between CS-CMV, MFR, and clinical outcomes.

Results

Thirty-two (31.1%) of 103 HT patients developed CS-CMVi at a median 9 months after HT. Patients with CS-CMVi had a signific

SUBMITTER: Gondi KT 

PROVIDER: S-EPMC11877306 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature