Lavage cytology diagnosed by immunostaining may be a poor prognostic factor in pathological stage III colorectal cancer.

ABSTRACT:

Aim

To clarify the prognostic impact of positive lavage cytology diagnosed by immunostaining on long-term outcomes following curative resection for pathological stage III colorectal cancer (CRC).

Method

We retrospectively investigated patients who underwent radical resection and intraoperative lavage cytology (LCY) simultaneously for pathological stage III primary CRC between 2005 and 2017. All LCY specimens were evaluated by Papanicolaou staining and immunostaining for carcinoembryonic antigen and Ber-EP4. Only Class V diagnosed by either staining method was defined as positive LCY, and patients were classified into two groups: a positive lavage cytology (LCY+) group; and a negative lavage cytology (LCY-) group. Overall survival (OS) and relapse-free survival (RFS) were com

SUBMITTER: Nankaku A 

PROVIDER: S-EPMC11877335 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature