The Reciprocal Relationship Between Short- and Long-Term Motor Learning and Neurometabolites.

ABSTRACT: Skill acquisition requires practice to stimulate neuroplasticity. Changes in inhibitory and excitatory neurotransmitters, such as gamma-aminobutyric acid (GABA) and glutamate, are believed to play a crucial role in promoting neuroplasticity. Magnetic resonance spectroscopy (MRS) at 3 T, using the MEGA-PRESS sequence, and behavioral data were collected from 62 volunteers. Participants completed a 4-week protocol, practicing either complex (n = 32) or simple (n = 30) bimanual tracking tasks (BTT). Neurotransmitter levels and skill levels at baseline, after 2 and 4 weeks of motor training were compared for the left and right primary sensorimotor cortex (SM1) and the left dorsal premotor cortex (PMd). Furthermore, task-related modulations of neurotransmitter levels in the left PMd were assesse

SUBMITTER: Hehl M 

PROVIDER: S-EPMC11877351 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature