Multivitamins After Myocardial Infarction in Patients With Diabetes: A Randomized Clinical Trial.

ABSTRACT:

Importance

In 2013, the Trial to Assess Chelation Therapy (TACT) reported that in 1708 patients with stable coronary disease and prior myocardial infarction (MI), oral multivitamins and multiminerals (OMVMs), in a factorial design with edetate disodium (EDTA) chelation therapy, did not reduce cardiovascular events relative to placebo OMVMs, but active EDTA combined with active OMVMs was superior to placebo OMVM/placebo EDTA.

Objective

To compare OMVM vs placebo in terms of efficacy for reducing major adverse cardiovascular events in patients with diabetes and prior MI.

Design, setting, and participants

The TACT2 randomized, multicenter double-masked 2 × 2 factorial clinical trial took place across 88 sites in the US and Canada. Participants were 50 years or older, had

SUBMITTER: Ujueta F 

PROVIDER: S-EPMC11877407 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature