The Causal Relationship Between Acne Vulgaris and BMI: A Mendelian Randomization Study.

ABSTRACT:

Background

As an inflammatory skin condition, acne usually presents with a complex pathogenesis. Recent studies suggest that BMI may relate to the incidence of acne. Mendelian randomization is a statistical method that is used to evaluate the causal effects of exposure factors on outcome variables.

Methods

We applied the inverse-variance weighted (IVW) method to evaluate the causal effect as the primary analysis between BMI and acne in our two-sample Mendelian randomization study. We included 58 SNPs accounting for 2.5% (R²) of the BMI variation as instrumental variables (IVs) for BMI-acne causal estimations.

Result

The F-statistic obtained from the first stage of the MR regression model was 61. Importantly, the results from all three methods consistently i

SUBMITTER: Li Z 

PROVIDER: S-EPMC11877415 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature