Intensity of statin therapy after ischaemic stroke and long-term outcomes: a nationwide cohort study.

ABSTRACT:

Background

Statins are essential for secondary prevention after ischaemic stroke (IS). However, statin intensity recommendations differ, and there is a concern about intracerebral haemorrhage (ICH). We studied the long-term impacts of initial statin intensity following IS.

Methods

Consecutive patients using high-intensity, moderate-intensity or low-intensity statin early after IS (n=45 512) were retrospectively studied using national registries in Finland. Differences were adjusted using multivariable regression. The primary outcome was all-cause death within 12-year follow-up (median 5.9 years). Secondary outcomes were recurrent IS, cardiovascular death and ICH studied using competing risk analyses.

Results

High-intensity therapy was initially used by 16.0%, moderate

SUBMITTER: Kyto V 

PROVIDER: S-EPMC11877428 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature