Left atrial appendage closure in patients with atrial fibrillation and acute ischaemic stroke despite anticoagulation.

ABSTRACT:

Background

The occurrence of acute ischaemic stroke (AIS) while using oral anticoagulants (OAC) is an increasingly recognised problem among nonvalvular atrial fibrillation (NVAF) patients. We aimed to elucidate the potential role of left atrial appendage closure (LAAC) for stroke prevention in patients with AIS despite OAC use (AIS-despite-OAC).

Methods

We retrospectively collected baseline and follow-up data from consecutive NVAF patients who had AIS-despite-OAC and subsequently underwent endovascular LAAC, between January 2015 and October 2021. The primary outcome measure was the occurrence of AIS after LAAC, and the safety outcome was symptomatic intracerebral haemorrhage (ICH).

Results

29 patients had LAAC specifically because of AIS-despite-OAC. The mean age at t

SUBMITTER: Abramovitz Fouks A 

PROVIDER: S-EPMC11877432 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature