Left atrial appendage closure for patients with atrial fibrillation at high intracranial haemorrhagic risk.

ABSTRACT:

Background and objectives

Although left atrial appendage closure (LAAC) is performed in patients with non-valvular atrial fibrillation (NVAF) at increased risk of intracranial haemorrhage (ICH), outcome data are scarce. We assessed the detailed neurological indications for LAAC and outcomes after LAAC in high ICH risk patients.

Methods

Study population included consecutive patients with NVAF who underwent LAAC in a single hospital network between January 2015 and October 2021 because of prior ICH or the presence of high ICH risk imaging markers on brain MRI (cerebral microbleeds (CMBs)). Primary safety and efficacy outcome measures were the occurrence of ICH and thromboembolic events, respectively, after LAAC.

Results

Among 146 patients with NVAF who underwent LAAC fo

SUBMITTER: Abramovitz Fouks A 

PROVIDER: S-EPMC11877437 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature