Capsular stem cell function and tissue composition are associated with symptoms and radiographic severity in people with knee osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is associated with lost range of motion in the affected joint(s). Evidence suggests that this may be due to increased activity of posterior capsule fibroblasts, cells in turn derived from mesenchymal stromal cells (MSCs).

Objectives

To test the hypotheses that (1) MSCs are more numerous in the posterior capsule of patients with knee flexion contracture (FC) and (2) in OA participants with knee FC, the MSC population in the posterior capsule differentiates toward a fibrotic phenotype. In order to complete these objectives, we looked for associations between capsule histologic and MSC outcomes with clinical outcomes.

Design

Cross-sectional translational research design using data from the Ottawa Knee Osteoarthritis (OKOA) database.

Meth

SUBMITTER: Campbell TM 

PROVIDER: S-EPMC11877474 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature