Population pharmacokinetics of colistin sulfate in patients on continuous veno-venous hemodiafiltration.

ABSTRACT:

Objective

The aim of this study is to establish a population pharmacokinetic (PK) model for patients undergoing continuous veno-venous hemodiafiltration (CVVHDF) and optimize the dosing regimen of colistin sulfate.

Methods

A prospective observational study in a single center was conducted on patients who were administrated with colistin sulfate and CVVHDF for at least 48 h. Blood samples were obtained prior to dosing and four to six blood samples (primarily C_0.5h, C_1h, C_2h, C_4h, and C_6h) after dosing. The blood concentration of colistin sulfate was determined by ultra-high performance liquid chromatography-tandem mass spectrometry assay. The NONMEM program was used to establish the population PK model and perform Monte C

SUBMITTER: Huang T 

PROVIDER: S-EPMC11877486 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature