Cytotoxic Stilbenoids, Hetero- and Homodimers of Homoisoflavonoids from <i>Prospero autumnale</i>.

ABSTRACT: An activity-guided isolation study on the EtOH extract prepared from the bulbs of Prospero autumnale yielded four new phenolic compounds, including a new stilbenoid (1), a new homoisoflavonoid derivative (8), a new homoisoflavonoid dimer (9), and an unprecedented homoisoflavone-stilbene heterodimer (10), together with six known (2-7) analogs. Their chemical structures were elucidated by spectroscopic analysis and theoretical NMR and ECD calculations. Compounds 9 and 10 are unique in their scaffolds. The in vitro cytotoxic activity of purified compounds was evaluated against eight tumor cell lines (HCT116, LoVo, DU145, PC3, HEP3B, HEPG2, MCF7, and MDA-MB-231) and one nontumor cell line (L929) by the MTS assay. Compounds <

SUBMITTER: Kırmızıbekmez H 

PROVIDER: S-EPMC11877502 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature