Fatuamide A, a Hybrid PKS/NRPS Metallophore from a <i>Leptolyngbya</i> sp. Marine Cyanobacterium Collected in American Samoa.

ABSTRACT: A structurally novel metabolite, fatuamide A (1), was discovered from a laboratory cultured strain of the marine cyanobacterium Leptolyngbya sp., collected from Faga'itua Bay, American Samoa. A bioassay-guided approach using NCI-H460 human lung cancer cells directed the isolation of fatuamide A, which was obtained from the most cytotoxic fraction. The planar structure of fatuamide A was elucidated by integrated NMR and MS/MS analysis, and a combination of bioinformatic and computational approaches was used to deduce the absolute configuration at its eight stereocenters. A putative hybrid PKS/NRPS biosynthetic gene cluster responsible for fatuamide A production was identified from the sequenced genomic DNA of the cultured cyanobacterium. The biosynthetic gene cluster possessed

SUBMITTER: Alexander KL 

PROVIDER: S-EPMC11877528 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature