The cGAS-STING-related signature affects the prognosis of colorectal cancer through its regulation of multiple immune cells.

ABSTRACT: The cGAS-STING signaling pathway has emerged as a critical player in the immune response against cancer, including colorectal adenocarcinoma (COAD). Understanding the impact of this pathway on COAD at multiple omics levels is crucial for advancing cancer immunotherapy and precision medicine. This study aimed to investigate the relationship between cGAS-STING-related genes and COAD, analyzing gene mutations, copy number variations, DNA methylation, and gene expression to uncover the pathway's influence on COAD prognosis. Utilizing multi-omics sequencing data from TCGA and GEO databases, key core genes in the cGAS-STING pathway were identified and further validated through PCR and Western blot analysis. Mutations and copy number variations in the CASP8 and RIPK1 genes, differential DNA methy

SUBMITTER: Li Y 

PROVIDER: S-EPMC11877623 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature