Self-referenced Digital Spectral Chromatic Local Surface Plasmon Resonance in Ultrasensitive Severe Sepsis Interleukin-6 Detection.

ABSTRACT: Clinical monitoring of cytokines, such as interleukin-6 (IL-6), enables a timely diagnosis and can significantly improve patient prognosis. In this study, we developed a rapid, label-free, ultrasensitive, and low matrix-effect method called chromatic digital nanoplasmon-metry (cDiNM) to detect IL-6 in human blood plasma. Utilizing a multiple filter configuration, two nonadjacent specific transmission wavelength bands are extracted. One is centered within the full-width-at-half-maximum (fwhm) range where the local surface plasmon resonance (LSPR) response of the 80 nm gold nanoparticles (AuNPs) is strongest, while the other band is narrowed and blue-shifted from the peak to a region with minor intensity change. Scattering images of AuNPs passing through these two bands are then captured sim

SUBMITTER: Chang TW 

PROVIDER: S-EPMC11877628 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature