Antibody correlates of risk of clinical malaria in an area of low and unstable malaria transmission in western Kenya.

ABSTRACT:

Background

Defining antibody correlates of protection against clinical malaria in areas of low and unstable transmission is challenging because of limited malaria cases in these areas. Additionally, clinical malaria affects both adults and children in areas of low and unstable transmission, but it is unclear whether antibody correlates of protection against malaria differ with age.

Methods

Blood samples were obtained from 5753 individuals in Kenyan highland area with low and seasonal malaria transmission in 2007 and recorded episodes of clinical malaria in this population from 2007 to 2017. Using a nested case-control study design, participants who developed clinical malaria (cases) were matched by age and village to those who did not (controls). Immunoglobulin (Ig)G, IgG1,

SUBMITTER: Odhiambo EO 

PROVIDER: S-EPMC11877692 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature