Synaptic protein CSF levels relate to memory scores in individuals without dementia.

ABSTRACT:

Background

We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity on these associations.

Methods

We included 242 CN (105(43%) abnormal amyloid), and 278 MCI individuals (183(66%) abnormal amyloid) from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery (EMIF-AD MBD) and the Alzheimer's Disease Neuroimaging Initiative (ADNI). For 181 (EMIF-AD MBD) and 36 (ADNI) proteins with a synaptic annotation in SynGO, associations with word learning recall were analysed with linear models.

Results

Subsets of synaptic proteins showed lower levels with worse recall in preclinical AD

SUBMITTER: Wesenhagen KEJ 

PROVIDER: S-EPMC11877693 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature