Genomic insights into the plasmidome of non-tuberculous mycobacteria.

ABSTRACT:

Background

Non-tuberculous mycobacteria (NTM) are a diverse group of environmental bacteria that are increasingly associated with human infections and difficult to treat. Plasmids, which might carry resistance and virulence factors, remain largely unexplored in NTM.

Methods

We used publicly available complete genome sequence data of 328 NTM isolates belonging to 125 species to study gene content, genomic diversity, and clusters of 196 annotated NTM plasmids. Furthermore, we analyzed 3755 draft genome assemblies from over 200 NTM species and 5415 short-read sequence datasets from six clinically relevant NTM species or complexes including M. abscessus, M. avium complex, M. ulcerans complex and M. kansasii complex, for the presence of these plasmids.

Results

Between one

SUBMITTER: Diricks M 

PROVIDER: S-EPMC11877719 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature