Genetic overlap between schizophrenia and constipation: insights from a genome-wide association study in a European population.

ABSTRACT:

Background

Patients with schizophrenia (SCZ) experience constipation at significantly higher rates compared with the general population. This relationship suggests a potential genetic overlap between these two conditions.

Methods

We analyzed genome-wide association study (GWAS) data for both SCZ and constipation using a five-part approach. The first and second parts assessed the overall and local genetic correlations using methods such as linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics (HESS). The third part investigated the causal association between the two traits using Mendelian randomization (MR). The fourth part employed conditional/conjunctional false discovery rate (cond/conjFDR) to analyze the genetic overlap with di

SUBMITTER: Luo Q 

PROVIDER: S-EPMC11877780 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature