An international observational study validating gene-expression sepsis immune subgroups.

ABSTRACT:

Background

Sepsis gene-expression sub-phenotypes with prognostic and theranostic potential have been discovered. These have been identified retrospectively and have not been translated to methods that could be deployed at the bedside. We aimed to identify subgroups of septic patients at high-risk of poor outcome, using a rapid, multiplex RNA-based test.

Methods

Adults with sepsis, in the intensive care unit (ICU) were recruited from 17 sites in the United Kingdom, Sweden and France. Blood was collected at days 2-5 (S1), 6-8 (S2) and 13-15 (S3) after ICU admission and analyzed centrally. Patients were assigned into 'high' and 'low' risk groups using two models previously developed for the Immune-Profiling Panel prototype on the bioMérieux FilmArray® system.

Results

357

SUBMITTER: Antcliffe DB 

PROVIDER: S-EPMC11877781 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature