Improving vulnerable Calbindin1^- neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory.

ABSTRACT:

Background

Intraneuronal accumulation of hyperphosphorylated tau is a hallmark of Alzheimer's disease (AD). Given the significant correlation between tau pathology and memory loss in AD patients, identifying vulnerable brain regions, particularly susceptible neuron types in these regions, will advance our understanding of AD onset and shed light on therapeutic strategies to manage its progression.

Methods

Immunofluorescent staining was employed to identify the brain regions and neuron types vulnerable to tau pathology in AD. A combination of chemogenetics, electrophysiological recording, in vivo Ca²⁺ recording, and a modified temporal-order discrimination behavior test was utilized to investigate the toxicity of tau accumulation to susceptible neurons in the dorsa

SUBMITTER: Lei H 

PROVIDER: S-EPMC11877784 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature