Efficacy and safety of corticosteroids for stroke and traumatic brain injury: a systematic review and meta-analysis.

ABSTRACT:

Background

Corticosteroids are frequently used in practice to treat patients with neurological disorders. However, its effect for stroke and traumatic brain injury (TBI) remains controversial. This study aimed to systematically review and evaluate efficacy and safety of corticosteroids for the treatment of stroke and TBI.

Methods

We searched Ovid-Medline and Ovid-Embase databases for randomised controlled trials (RCTs) and cohort studies evaluating the efficacy and safety of corticosteroids in patients with ischaemic stroke, intracerebral haemorrhage (ICH), subarachnoid haemorrhage (SAH) or TBI. The treatment intervention was corticosteroid, and the control was placebo or routine care. Outcome measures were death, functional outcomes and adverse events. We calculated odds ra

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11877790 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature