Histidine metabolism drives liver cancer progression via immune microenvironment modulation through metabolic reprogramming.

ABSTRACT:

Background

Histidine metabolism is crucial in role in tumor biology, contributing to tumor progression, immune regulation, and metabolic reprogramming. In hepatocellular carcinoma (HCC), dysregulated histidine metabolism may promote tumor growth and immune evasion, although the specific mechanisms remain poorly understood.

Methods

Using single-cell RNA sequencing, the expression patterns of histidine metabolism-related genes were evaluated across different cell types in HCC samples. In vivo and in vitro experiments were conducted to validate how histidine treatment affects macrophage and T-cell function. Furthermore, the TCGA database was utilized to construct a prognostic model to identify the key gene BUD23 and to examine its correlation with metabolism and immune infiltra

SUBMITTER: Liu P 

PROVIDER: S-EPMC11877819 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature