Molecular subtyping of stage I lung adenocarcinoma via molecular alterations in pre-invasive lesion progression.

ABSTRACT:

Background

Patients with adenocarcinoma in situ (AIS) and minimally invasive (MIA) lung adenocarcinoma (LUAD) are curable by surgery, whereas 20% stage I patients die within five years after surgery. We hypothesize that poor-prognosis stage I patients may exhibit key molecular characteristics deviating from AIS/MIA. Therefore, we tried to reveal molecularly and prognostically distinct subtypes of stage I LUAD by applying key molecular alterations from AIS/MIA to invasive LUAD progression.

Methods

The RNA and whole-exome sequencing data of 197 tumor-normal matched samples from patients with AIS, MIA, and invasive LUAD were analyzed. ddPCR quantified 202 samples from 182 patients at the absolute expression level. Immunohistochemical quantified the protein expression levels of

SUBMITTER: Shang J 

PROVIDER: S-EPMC11877874 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature