Causality of blood metabolites on hepatocellular carcinoma and cholangiocarcinoma: a metabolome-wide mendelian randomization study.

ABSTRACT:

Background

Reportedly, there is an association between body metabolites and the risk of Hepatocellular Carcinoma (HCC) & Cholangiocarcinoma (CCA), possibly due to disrupted metabolic pathways leading to oxidative stress and an imbalance in cell proliferation and apoptosis, thereby increasing the risk of cancer. However, whether metabolites play a role in the onset of HCC or CCA remains inconclusive.

Objective

The aim of our study is to explore the potential causal relationship between metabolites and the risk of HCC&CCA.

Methods

Our study investigated the causal relationship between 1400 metabolites and HCC&CCA using publicly available genome-wide association study data. Single nucleotide polymorphisms (SNPs) associated with both metabolites and HCC&CCA were chosen as

SUBMITTER: Ning L 

PROVIDER: S-EPMC11877886 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature