The importance of age as a prognostic predictor of childhood hepatoblastoma: an analysis of single-center childhood hepatoblastoma in China.

ABSTRACT:

Objective

The study investigates the impact of age at initial diagnosis on the prognosis of pediatric hepatoblastoma (HB) patients, aiming to provide a basis for optimizing risk stratification.

Methods

Data from 403 patients with HB diagnosed at the First Affiliated Hospital of Sun Yat-sen University between February 2010 and September 2023 were collected. Kaplan‒Meier survival analysis, Cox regression analysis, and binary logistic regression were employed for statistical analysis.

Results

The hazard ratios (HRs) for event-free survival (EFS) reduction in HB patients were 1, 0.862, 1.393, 2.008, 1.325, 1.859, 3.667 (P = 0.001), and 2.502 (P = 0.023) for first-diagnosis ages of 0-1, 1-2, 2-3, 3-4, 4-5, 5-6, 6-8, and ≥ 8 years, respectively. After adjusting for newly di

SUBMITTER: Li Z 

PROVIDER: S-EPMC11877914 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature