Contribution of brain pericytes to neuroinflammation following repetitive head trauma.

ABSTRACT:

Background

Neuroinflammation is a prominent pathological hallmark of traumatic brain injury (TBI) and glia cells have been widely characterized in the onset or progression of brain inflammation. While an effect of inflammation on cerebrovascular breakdown has been observed, little is known about the specific contribution of brain pericytes to the inflammatory response in TBI. Here, we focused on studying the pericyte response to inflammatory stimuli commonly found in the brain following TBI.

Methods

Mouse brain vascular pericytes were exposed to IL-1β, TNF-α and IFN-γ for 2 h and 24 h and probed for markers of pericyte health and a panel of inflammatory mediators. As the platelet-derived growth factor (PDGF) pathway is critical to pericyte function, we also assessed the effe

SUBMITTER: Cembran A 

PROVIDER: S-EPMC11877937 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature