Causal relationship between immune cell signatures and colorectal cancer: a bi-directional, two-sample mendelian randomization study.

ABSTRACT:

Background

Prior studies have demonstrated the association between immune cells and colorectal cancer (CRC). However, the causal link to specific immunophenotypes is limited. This study intends to elucidate the causal relationship of immune cell signatures on CRC.

Methods

We performed a bi-directional and two-sample mendelian randomization (MR) study, utilizing GWAS summary data of 731 immune cell traits (n = 3,757) and CRC statistics (n = 470,002). The primary MR methodology was inverse-variance weighted (IVW) method. Furthermore, heterogeneity was evaluated by Cochran's Q test. MR-PRESSO and MR-Egger were employed to assess horizontal and vertical pleiotropy respectively. Sensitivity analysis and FDR correction were conducted in our results. These results were validated in

SUBMITTER: Liu R 

PROVIDER: S-EPMC11877943 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature