Integrated multiomic profiling of tail adipose tissue highlights novel genes, lipids, and metabolites involved in tail fat deposition in sheep.

ABSTRACT:

Background

Tail fat is important for fat-tailed or fat-rumped sheep to survive in harsh environments. However, the molecular mechanism underlying tail fat deposition in sheep remains unclear. In this study, we comprehensively characterized the transcriptome, untargeted lipidome, and targeted metabolome profiles of the tail adipose tissues from Large-tailed Han sheep (long fat-tailed sheep) and Hu sheep (short fat-tailed sheep).

Results

We identified 183 differentially expressed genes (DEGs), 55 differential lipids (DLs) and 17 differential metabolites (DMs) in the adipose tissues of the tails from Large-tailed Han and Hu sheep. Among the 183 DEGs selected (Q values ≤ 0.05 and│Log₂(FC)│≥ 0.5), 18 DEGs, such as UCP3, ELOVL7 and GDF10, were directly associated with l

SUBMITTER: Xie Y 

PROVIDER: S-EPMC11877962 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature