Novel PiuC, PirA, and PiuA mutations leading to <i>in vivo</i> cefiderocol resistance progression in IMP-16- and KPC-2-producing <i>Pseudomonas aeruginosa</i> from a leukemic patient.

ABSTRACT: Pseudomonas aeruginosa is an opportunistic pathogen capable of causing severe infections in immunocompromised individuals, who often require prolonged antibiotic therapy. The emergence of carbapenemase-producing P. aeruginosa has further complicated the management of nosocomial infections, limiting therapeutic options. Cefiderocol has recently emerged as a promising antipseudomonal agent, using the bacterial iron transport system to gain entry into the cell; however, there have been reports of P. aeruginosa resistant to cefiderocol. We describe the in vivo cefiderocol resistance progression of four consecutive P. aeruginosa isolates from one patient with T-cell acute lymphoblastic leukemia. Analysis of potential genes involved in cefiderocol transport res

SUBMITTER: Vines J 

PROVIDER: S-EPMC11878004 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature