Macrolide resistance due to <i>erm</i>(55).

ABSTRACT: Antimicrobial resistance (AMR) is a global threat. The identification and characterization of novel resistance genes is integral to AMR surveillance. The erm(55) gene was originally identified through whole genome sequencing of macrolide-resistant strains of Mycobacterium chelonae. The gene was annotated as a ribosomal methyltransferase, but its role as a determinant of macrolide resistance was not formally demonstrated. Three erm(55) alleles have now been documented. The plasmid-borne erm(55)^P, the transposon-associated erm(55)^T, and the chromosomal encoded erm(55)^C exhibit ≈82% amino acid sequence identity. Here, we confirm that, when expressed from plasmids in a macrolide-susceptible strain of Escherichia coli

SUBMITTER: Alexander DC 

PROVIDER: S-EPMC11878018 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature