Emergence of concurrently transmissible <i>mcr-9</i> and carbapenemase genes in bloodborne colistin-resistant <i>Enterobacter cloacae</i> complex isolated from ICU patients in Kolkata, India.

ABSTRACT: Colistin resistance in carbapenem-resistant Enterobacter cloacae complex (CR-ECC) infections has grown expeditiously but detecting the underlying mechanism of resistance is often challenging in clinical settings. This study, first of its kind from India, determined the resistance mechanisms and characterized colistin-resistant hospital isolates. Twenty-nine bloodborne CR-ECC isolated from ICU patients of eight tertiary care hospitals in Kolkata, India between 2022 and 2023 were screened for colistin resistance. The plasmid-encoded mcr-9 gene, acrAB-tolC efflux pump (EP) & phoP/Q, and pmr A/B two-component system (TCS) involved in colistin resistance were examined. In addition, AMR gene profiling and molecular subtypes of mcr-9-producing CR-ECC isol

SUBMITTER: Halder G 

PROVIDER: S-EPMC11878022 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature