Exploring the effect of sequential antibiotic exposure in resistant <i>Escherichia coli</i> causing urinary tract infections: a proof of principle study.

ABSTRACT: Antimicrobial resistance development, particularly in infections such as urinary tract infections (UTIs), is a global clinical concern. The objective of this study was to determine if sequential antibiotic exposure with ciprofloxacin and mecillinam can reduce the growth of resistant clinical Escherichia coli strains, thus improving the effectiveness of antibiotic therapy. Six E. coli isolates with heterogeneous resistance to ciprofloxacin and/or mecillinam obtained from patients with UTIs were exposed to one of the antibiotics (0.75 × minimum inhibitory concentration, MIC) for 1 h. This was followed by treatment with the second antibiotic at different concentrations (0.0375/0.075/0.375/0.75 × MIC). Continuous growth measurements were conducted in order to assess the impact of

SUBMITTER: Gopel L 

PROVIDER: S-EPMC11878055 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature