Regulation of IL-10 production in dendritic cells is controlled by the co-activation of TLR2 and Mincle by <i>Lactiplantibacillus plantarum</i> OLL2712.

ABSTRACT: We showed that Lactiplantibacillus plantarum OLL2712 (OLL2712) strongly induces interleukin (IL)-10 production in immune cells. Although beneficial effects of this strain have been observed in both mice and humans, the mechanisms underlying IL-10 induction remain unclear. In this study, we found that OLL2712 co-activates two pattern recognition receptors, leading to IL-10 production in the mouse-derived thermosensitive dendritic cell line, tsDC. We first revealed the involvement of the Toll-like receptor (TLR)2-Myeloid differentiation primary response gene (MYD) 88 pathway in OLL2712-induced IL-10 production in tsDCs. However, stimulation with the TLR2 agonist alone was insufficient to induce IL-10 production. Consequently, we explored additional signaling pathways and found that th

SUBMITTER: Sakabe R 

PROVIDER: S-EPMC11878067 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature