Study of the probability of resistance to phage infection in a collection of clinical isolates of <i>P</i>s<i>eudomonas aeruginosa</i> in relation to the presence of Pf phages.

ABSTRACT: Pseudomonas aeruginosa is a bacterial pathogen that is a major cause of lung infections in cystic fibrosis (CF) and other patients. Isolates of P. aeruginosa from CF patients commonly carry filamentous phages (Pf phages), which constitute a family of temperate phages known to be related to biofilm production and antibiotic sequestration. In this study, we identified 12 new Pf phage genomes in a collection of clinical isolates of P. aeruginosa from CF patients. Study of the anti-phage defense systems in the bacterial isolates revealed the presence of 89 such systems, of which eight were encoded in the Pf phage genomes. Finally, although a weak relation between resistance to phage infection and the number of anti-phage defense systems was detected, it was observed that t

SUBMITTER: Blasco L 

PROVIDER: S-EPMC11878078 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature